Comparison of finasteride (Proscar) and Serenoa repens (Permixon)
Study
Comparison of finasteride (Proscar) and Serenoa
repens (Permixon) in the inhibition of 5-alpha reductase in healthy male
volunteers.
AUTHOR
Strauch G; Perles P; Vergult G; Gabriel
M; Gibelin B; Cummings S; Malbecq W; Malice MP
ORGANISATION
Eclimed Pharmacologie Clinique, Hopital
Universitaire Cochin, Paris, France.
SOURCE
Eur Urol 1994; 26 (3):
247-52
LANGUAGE
English
ABST: A total of 32 healthy male
volunteers (age range 20-30 years) were enrolled in a 1-week open, randomized,
placebo-controlled study comparing finasteride (Proscar), a 5 alpha-reductase
inhibitor, with Permixon, the plant extract of Serenoa repens. The objective of
the study was to evaluate the effect of single and multiple doses of the drugs
on the inhibition of 5 alpha-reductase as assessed by serum dihydrotestosterone
level determination. Following baseline measurements on day 1, the subjects were
randomized to finasteride 5 mg once a day (n=10), Permixon 80 mg x 2 twice a day
(n=11), or to placebo once a day (n=11) for 7 days. Serum testosterone and
dihydrotestosterone levels, were determined on day 1 (baseline and 12 h) and on
days 2 (24 h), 3 (48 h), 4 (72 h), 6 (120 h), and 8 (168 h). After 12 h, a
single dose of finasteride 5 mg reduced the serum dihydrotestosterone level by
65% (p < or=0.01). The decreases ranged from -52 to -60% with multiple doses
of finasteride 5 mg once a day (p < or=0.01). As in the placebo group, there
was no effect of Permixon on the serum dihydrotestosterone level. No significant
difference was detected between finasteride and Permixon or between finasteride
and placebo with respect to serum testosterone, except on days 3 and 6,
respectively (p < or=0.05). However, the corresponding serum testosterone
levels remained within the normal ranges. These data confirm the efficacy of
finasteride as inhibitor of 5 alpha-reductase.(ABSTRACT TRUNCATED AT 250 WORDS)
(AUTHOR)
MJTR: Androgen Antagonists PD.
Finasteride PD. Plant Extracts PD. Testosterone 5-alpha-Reductase AI.
MNTR: Adult. Androgen Antagonists AD.
Comparative Study. Finasteride AD. Finasteride AE. Human. Male. Plant Extracts
AD. Plant Extracts AE. Stanolone BL. Testosterone BL. CLINICAL TRIAL. JOURNAL
ARTICLE. RANDOMIZED CONTROLLED TRIAL
RNUM: EC 1.3.99.5 (Testosterone
5-alpha-Reductase); 0 (Androgen Antagonists); 0 (Permixon); 0 (Plant Extracts);
521-18-6 (Stanolone); 57-85-2 (Testosterone); 98319-26-7 (Finasteride)
GEOT: SWITZERLAND
IDEN: ISSN: 0302-2838. JOURNAL-CODE:
ENM. ENTRY-DATE: 950131. JOURNAL-SUBSET: M. IM-DATE: 9504.
ACCE: 95104266
